genetic linkage (3 marks) In humans, the COAGULATION FACTOR VIII (or F8) gene is associated: Fatima Assignment, UAE

Assignment 2  General genetics, Spring 2023 Due date: 10 Nov 2023 (11.59 PM) 
(a) genetic linkage (3 marks) In humans, the COAGULATION FACTOR VIII (or F8) gene is associated with Hemophilia A, the COAGULATION FACTOR IX (F9) gene is associated with Hemophilia B, and the GREEN CONE PIGMENT (GCP) gene is associated with color blindness disorder. These disorders are X-linked recessive type, which means the genes associated with these disorders are located on the X chromosome and their mode of inheritance is recessive type. The positions of F8, F9, and GCP genes on the X chromosome are following: 
F8: (start) 154,835,791 - 155,022,722 (end) F9: (start) 139,530,719 - 139,563,458 (end) GCP: (start) 154,182,595 - 154,196,860 (end) 

Based on these details, please address the following questions. 
(1) In the first scenario: a perfectly healthy man marries a woman who has both Color blindness and Hemophilia B disorders. How likely is it that their son will have both disorders? Explain this by incorporating the genetic linkage concept. 

(2) In the second scenario: In generation I, a perfectly healthy woman (not a carrier) marries a man who has both Color blindness and Hemophilia B disorders. In Generation II, they have a daughter who marries a healthy man. How likely is it that their son, in generation III, will have both disorders? Explain this by incorporating the genetic linkage concept. 

(3) What will be the recombinant frequency for Color blindness vs Hemophilia B, and Colorblindness vs Hemophilia A? 

(b) Mutation (1 Mark) Let's suppose that the DNA is exposed to UV light and because of that, DNA damage has occurred. Such damages are often corrected by the DNA-repair mechanisms of the cell. However, if there is a mutation in a protein that is a part of the DNA-repair mechanism system, how will that mutation affect the DNA damage repair?